TreeFrog Therapeutics I iPS-derived cell therapies https://treefrog.fr Cell Therapy for All Tue, 07 Feb 2023 15:37:25 +0000 en-US 1.2 https://treefrog.fr/ https://treefrog.fr 1 https://wordpress.org/?v=5.8.6 https://treefrog.fr/wp-content/uploads/2021/04/TreeFrog-Therapeutics-fav-150x150.jpg TreeFrog Therapeutics I iPS-derived cell therapies | https://treefrog.fr 32 32 <![CDATA[Careers]]> https://treefrog.fr/careers-stem-cell-jobs/ Thu, 01 Apr 2021 09:39:35 +0000 https://treefrog.fr/?page_id=18 Careers at TreeFRog Therapeutics

Get aboard!
Become a Froggy!

See open positions and apply!
Cell THERAPY FOR ALL

TreeFrog Therapeutics was created in 2018 with the goal of providing access to safer, more efficient and more affordable cell therapies to millions of patients.

Our motto "Cell Therapy for All" encapsulates this vision.

Learn more about us https://youtu.be/F_q_dp5iNA8
Our core values

#Do

Since the very inception of TreeFrog, our focus was to try and make it simple. We recruit doers and service our partners with the same collective mindset.

#Trust

Our moto “Cell Therapy for all” means that our business is about being entrusted by a large array of stakeholders. Maintaining a culture of trust is therefore a priority for us.

#Be bold

We introduce a breakthrough technology for cell therapy manufacturing and we intend to remain a technological leader. We dare to go forth with new ideas, push the limits and sustain great ambitions.

#Commit

Our commitment is to mass-produce safe and affordable cells for millions of patients awaiting for treatment. Our responsibility is to bring as fast as possible novel cell therapies to the market and ensure best-in-class quality.

#Enjoy

We believe working together should make us happier and more fulfilled human beings. It means adapting to each one’s definition of pleasure and happiness, and communicating joy in any way we can.

Working at TreeFrog

Words of mouth

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]]> <![CDATA[Cell therapy pipeline]]> https://treefrog.fr/cell-therapy-pipeline-ips-derived-cell-therapies-allogeneic-stem-cell-therapies/ Thu, 01 Apr 2021 09:40:20 +0000 https://treefrog.fr/?page_id=23 NEXT-GEN CELL THERAPIES

Ready-to-graft microtissue formats

To unleash the therapeutic potential of stem cell-derived cell therapies

AN OPEN INNOVATION PIPELINE

Our goal is to bring the benefits of C-Stem™ as fast as possible to patients. To do so, we advance proprietary cell therapy programs and partner with leading initiatives from the industry and the academia.

Learn about C-Stem TreeFrog Therapeutics cell therapy pipeline
Lead programme

Neural microtissues to cure Parkinson's disease

In contrast with cell therapy approaches based on the transplantation of single cells, the C-Stem™ technology generates 3D neural microtissues containing mature dopaminergic neurons. 

Since 2018, preclinical studies demonstrated robust in vivo effects and safety profile, with fast and complete motor function recovery. 

Aiming at a first-in-human trial in 2025, TreeFrog is now moving forward with regulatory toxicology studies and is transferring the GMP C-Stem™ platform to a CDMO to manufactue clinical-grade batches.

Neural microtissue containing mature dopaminerguic neurons differentiated
from human induced pluripotent stem cells cultured in 3D using C-Stem™ technology

Co-development & Licensing opportunities

Contact our team






    Cell Therapy Pipeline I iPS-derived cell therapies I Allogeneic Stem Cell Therapies

    TreeFrog Therapeutics is advancing a pipeline of hiPSC-derived cell therapies based on the C-Stem technology. Our lead programme is an iPS-based cell therapy for Parkinson's disease, which will reach IND and Phase I in 2025. We are also developing allogeneic therapies for heart failure with hiPSC-derived cardiac cells, iPS-derived HSC transplants with the EFS, iPS-derived CAR & NK cell therapies for oncology, iPS-derived cell therapies for AMD, as well as exploratory cell therapies for hepatic and pancreatic diseases (acute liver failure and Diabetes Type I)

    ]]> 23 0 0 0 In contrast with cell therapy approaches based on the transplantation of single cells, the C-Stem\u2122 technology generates 3D neural microtissues containing mature dopaminergic neurons. <\/span><\/p>\n

    Since 2018, preclinical studies demonstrated robust in vivo effects and safety profile, with fast and complete motor function recovery. <\/span><\/p>\n

    Aiming at a first-in-human trial in 2025, TreeFrog is now moving forward with regulatory toxicology studies and is transferring the GMP <\/span>C-Stem\u2122<\/span> platform to a CDMO to manufactue clinical-grade batches.<\/span><\/p>","text_color":"#FFFFFF","typography_typography":"custom","typography_font_family":"Roboto","typography_font_weight":"300","__globals__":{"text_color":"","typography_typography":""}},"elements":[],"widgetType":"text-editor"},{"id":"c6cb0bf","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"}],"isInner":true},{"id":"84f7b52","elType":"column","settings":{"_column_size":50,"_inline_size":62.768},"elements":[{"id":"b8ca74b","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/duotone-1.png","id":220},"align":"center","opacity":{"unit":"px","size":1,"sizes":[]},"_animation":"fadeInUp"},"elements":[],"widgetType":"image"},{"id":"3a22809","elType":"widget","settings":{"editor":"

    Neural microtissue containing mature dopaminerguic neurons differentiated
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    Cell Therapy Pipeline I iPS-derived cell therapies I Allogeneic Stem Cell Therapies<\/h1>\n

    TreeFrog Therapeutics is advancing a pipeline of hiPSC-derived cell therapies based on the C-Stem technology. Our lead programme is an iPS-based cell therapy for Parkinson's disease, which will reach IND and Phase I in 2025. We are also developing allogeneic therapies for heart failure with hiPSC-derived cardiac cells, iPS-derived HSC transplants with the EFS, iPS-derived CAR & NK cell therapies for oncology, iPS-derived cell therapies for AMD, as well as exploratory cell therapies for hepatic and pancreatic diseases (acute liver failure and Diabetes Type I)<\/p>"},"elements":[],"widgetType":"text-editor"}],"isInner":false}],"isInner":false}]]]> ]]> <![CDATA[About us]]> https://treefrog.fr/ips-stem-cell-therapy-biotech-company/ Thu, 01 Apr 2021 09:40:38 +0000 https://treefrog.fr/?page_id=25 About TreeFRog Therapeutics

    We bring together biophysicists, stem cell biologists & bioproduction engineers around the motto
    "Cell Therapy for All"

    THE VISION

    TreeFrog Therapeutics was created to provide access to safe, efficient and affordable cell therapies for millions of patients.

    https://youtu.be/F_q_dp5iNA8 Learn about C-Stem™
    TreeFrog Today

    Hyper-growth since incorporation in 2018

    0 + team $ 0 M raised since 2018 0 patents 0 sites worldwilde We're expanding in France, USA, and Japan. Join us!
    EXecutive team

    Frédéric Desdouits, PhD

    Chief Executive Officer
    Kévin Alessandri TreeFrog Therapeutics

    Kévin Alessandri, PhD

    Co-Founder, Chief Technology Officer

    Maxime Feyeux, PhD

    Co-Founder, Chief Scientific Officer
    Marie Catoire TreeFrog

    Marie Daniel Catoire, MBA

    General SECRETARY
    Gabriel Chaigneau TreeFrog

    Gabriel Chaigneau, MSc

    Chief Finance officer
    myriam m

    Myriam Makhloufi, MSc

    BUSINESS STRATEGY OFFICER

    Michael Lanero Fidalgo, MBA

    Chief Operating Officer
    Board members
    elsy boglioli

    Elsy Boglioli

    Chair, INDEPENDENT board MEMBER

    Frédéric Desdouits, PhD

    Chief Executive Officer
    Kévin Alessandri TreeFrog Therapeutics

    Kévin Alessandri, PhD

    Co-Founder, Chief Technology Officer

    Melissa Carpenter, PhD

    independEnt board MEMBER
    Peter Nell

    Peter Nell, PhD

    independEnt board MEMBER
    Board-Laurent-Higueret

    Laurent Higueret

    BPI Large Venture
    Pete Zippelius

    Pete Zippelius

    Leonard Green & Partners

    Guilhem de Vregille

    Xange

    Marine Choplain

    ObservER, Bpifrance
    bryan campbell

    Bryan Campbell

    Observer, BRISTOL-MYERS SQUIBB
    Board

    Camille Le Roux Larsabal

    Observer, AQUITI Gestion

    Maxime Feyeux, PhD

    Observer, Co-Founder and CSO
    SCIENTIFIC ADVISORY BOARD
    Prof Peter Andrews

    Prof. Peter Andrews

    Emeritus Professor, University of Sheffield, UK
    Prof L Mahadevan

    Prof. L. Mahadevan

    Professor of Physics, de Valpine Professor of Applied Mathematics, Professor of Organismic and Evolutionary Biology, Harvard University, USA
    Marta Shahbazi

    Marta Shahbazi, PhD

    Group Leader, MRC Laboratory of Molecular Biology (LMB) Cambridge, UK
    Justin Eyquem

    Justin Eyquem, PhD

    Assistant Professor, University of California San Francisco, Co-founder of Mnemo Therapeutics, USA
    Shin Kawamata

    Shin Kawamata, MD, PhD

    Director, Research and Development Center for Cell Therapy, FBRI Kobe, Japan
    Pierre Nassoy

    Pierre Nassoy, PhD

    Research Director, CNRS,
    co-inventor of C-SteM technology, Bordeaux, France
    They trust us

    Our partners

    eic scaling up logo French tech 120
    Scientific COLLABORATions
    INvestors
    Public funding
    EARLY SUPPORT
    European Commission

    TreeFrog Therapeutics is receiving funding from the European Union’s Horizon 2020 research and innovation program through the SME Instrument Phase 2 under grant agreement n° SME 881113.

    Logo Feder Nouvelle-Aquitaine

    La Région et l’Union européenne soutiennent le projet CHAMBERLAN dans le cadre du « Programme Opérationnel FEDER/FSE Aquitaine 2014-2020 » en conformité avec la règlementation européenne en matière de Fonds européens structurels et d’investissement (FESI).

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    TreeFrog Therapeutics is receiving funding from the European Union\u2019s Horizon 2020 research and innovation program through the SME Instrument Phase 2 under grant agreement n\u00b0 SME 881113.<\/span><\/p>"},"elements":[],"widgetType":"text-editor"}],"isInner":true}],"isInner":true},{"id":"a6fa9a9","elType":"section","settings":{"structure":"20","qode_parallax_speed":"0","animation":"fadeInUp"},"elements":[{"id":"6601128","elType":"column","settings":{"_column_size":50,"_inline_size":14.909},"elements":[{"id":"c42c34e","elType":"widget","settings":{"space":{"unit":"px","size":12,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"425e2d0","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/Logo-FEDER.png","id":1128},"image_size":"medium"},"elements":[],"widgetType":"image"},{"id":"93638c7","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/logo-NA.jpg","id":1130},"image_size":"medium"},"elements":[],"widgetType":"image"}],"isInner":true},{"id":"74dbaea","elType":"column","settings":{"_column_size":50,"_inline_size":85.091},"elements":[{"id":"e92644f","elType":"widget","settings":{"editor":"

    La R\u00e9gion et l\u2019Union europ\u00e9enne soutiennent le projet\u00a0CHAMBERLAN dans le cadre du \u00ab\u00a0Programme Op\u00e9rationnel FEDER\/FSE Aquitaine 2014-2020\u00a0\u00bb en conformit\u00e9 avec la r\u00e8glementation europ\u00e9enne en mati\u00e8re de Fonds\u00a0<\/span>europ\u00e9ens<\/em>\u00a0structurels et d\u2019investissement (<\/span>FESI<\/em>).<\/span><\/p>"},"elements":[],"widgetType":"text-editor"}],"isInner":true}],"isInner":true},{"id":"bea473d","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"}],"isInner":false}],"isInner":false}]]]> ]]> ]]> <![CDATA[Team]]> https://treefrog.fr/?page_id=27 Thu, 01 Apr 2021 09:40:58 +0000 https://treefrog.fr/?page_id=27 27 0 0 0 <![CDATA[News]]> https://treefrog.fr/ips-cell-therapy-news/ Thu, 01 Apr 2021 09:41:13 +0000 https://treefrog.fr/?page_id=29 Latest news]]> 29 0 0 0 <![CDATA[Parkinson's disease cell therapy]]> https://treefrog.fr/?page_id=31 Thu, 01 Apr 2021 09:41:48 +0000 https://treefrog.fr/?page_id=31 31 0 0 0 <![CDATA[Publications]]> https://treefrog.fr/publications-scientific-papers-posters/ Thu, 01 Apr 2021 09:43:14 +0000 https://treefrog.fr/?page_id=36 Publications

    Scientific papers, posters & more

    Latest posters

    Up to 151 Millionfold Cumulated Expansion of Encapsulated hIPS Cells in Bioreactor Over 28 Days: Comparison with 2D Culture and Standard Spheroid Culture
    Production of a single batch of 15 billion hiPS cells within a 10L bioreactor with an exponential amplification factor of 276-fold in 6.59 Days.
    Up to 151 Millionfold Cumulated Expansion of Encapsulated hIPS Cells in Bioreactor Over 28 Days: Comparison with 2D Culture and Standard Spheroid Culture
    Up to 151 Millionfold Cumulated Expansion of Encapsulated hIPS Cells in Bioreactor Over 28 Days: Comparison with 2D Culture and Standard Spheroid Culture
    iPS-derived-Parkinson-s-cell-therapy-poster
    Robust & scalable process enables the transplantation of hPSC-derived functional microtissues composed of dopaminergic neurons with best-in-class results in preclinical model of Parkinson’s disease

    Download posters​

    [contact-form-7 id="2385" title="Download posters"]

    Founding publications

    ]]> 36 0 0 0 [contact-form-7 id=\"2385\" title=\"Download posters\"]<\/p>"},"elements":[],"widgetType":"text-editor"}],"isInner":false}],"isInner":false},{"id":"78b190b","elType":"section","settings":{"qode_parallax_speed":"0"},"elements":[{"id":"f315376","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"fb3bddb","elType":"widget","settings":{"space":{"unit":"px","size":64,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"da4ea65","elType":"widget","settings":{"title":"Founding publications","__globals__":{"title_color":"globals\/colors?id=secondary"}},"elements":[],"widgetType":"heading"},{"id":"346e541","elType":"widget","settings":{"space":{"unit":"px","size":64,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"98c1b95","elType":"widget","settings":{"editor":"
    • Trushko A, Di Meglio I, Merzouki A, Blanch-Mercader C, Abuhattum S, Guck J, Alessandri K, Nassoy P, Kruse K, Chopard B, Roux A. Buckling of an Epithelium Growing under Spherical Confinement. Dev Cell. 2020<\/strong> Sep 14;54(5):655-668.e6. doi: 10.1016\/j.devcel.2020.07.019. Epub 2020 Aug 14. PMID: 32800097; PMCID: PMC7497624.<\/a>

      <\/span><\/li>
    • Le Maout V, Alessandri K, Gurchenkov B, Bertin H, Nassoy P, Scium\u00e8 G. Role of mechanical cues and hypoxia on the growth of tumor cells in strong and weak confinement: A dual in vitro-in silico approach. Sci Adv. 2020<\/strong> Mar 25;6(13):eaaz7130. doi: 10.1126\/sciadv.aaz7130. PMID: 32232163; PMCID: PMC7096162.<\/a>

      <\/span><\/li>
    • Miguel L, Rovelet-Lecrux A, Feyeux M, Frebourg T, Nassoy P, Campion D, Lecourtois M. Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neurons. Stem Cell Res. 2019<\/strong> Oct;40:101541. doi: 10.1016\/j.scr.2019.101541. Epub 2019 Aug 23. PMID: 31522011.<\/a>

      <\/span><\/li>
    • Andrique L, Recher G, Alessandri K, Pujol N, Feyeux M, Bon P, Cognet L, Nassoy P, Bikfalvi A. A model of guided cell self-organization for rapid and spontaneous formation of functional vessels. Sci Adv. 2019<\/strong> Jun 12;5(6):eaau6562. doi: 10.1126\/sciadv.aau6562. PMID: 31206014; PMCID: PMC6561743.<\/a>

      <\/span><\/li>
    • Van Liedekerke P, Neitsch J, Johann T, Alessandri K, Nassoy P, Drasdo D. Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines. PLoS Comput Biol. 2019<\/strong> Mar 8;15(3):e1006273. doi: 10.1371\/journal.pcbi.1006273. PMID: 30849070; PMCID: PMC6538187.<\/a>

      <\/span><\/li>
    • Ruiz-Herrero T, Alessandri K, Gurchenkov BV, Nassoy P, Mahadevan L. Organ size control via hydraulically gated oscillations. Development. 2017<\/strong> Dec 1;144(23):4422-4427. doi: 10.1242\/dev.153056. PMID: 29183945.<\/a>

      <\/span><\/li>
    • Dom\u00e9jean H, de la Motte Saint Pierre M, Funfak A, Atrux-Tallau N, Alessandri K, Nassoy P, Bibette J, Bremond N. Controlled production of sub-millimeter liquid core hydrogel capsules for parallelized 3D cell culture. Lab Chip. 2016<\/strong> Dec 20;17(1):110-119. doi: 10.1039\/c6lc00848h. PMID: 27869911.<\/a>

      <\/span><\/li>
    • Alessandri K, Feyeux M, Gurchenkov B, Delgado C, Trushko A, Krause KH, Vignjevi\u0107 D, Nassoy P, Roux A. A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC). Lab Chip. 2016<\/strong> Apr 26;16(9):1593-604. doi: 10.1039\/c6lc00133e. PMID: 27025278.<\/a>

      <\/span><\/li>
    • Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, D\u00e9glon N. Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells. PLoS One. 2014<\/strong> Jun 13;9(6):e99341. doi: 10.1371\/journal.pone.0099341. PMID: 24926995; PMCID: PMC4057216.<\/a>

      <\/span><\/li>
    • Xu R, Feyeux M, Julien S, Nemes C, Albrechtsen M, Dinny\u00e9s A, Krause KH. Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay. AAPS J. 2014<\/strong> May;16(3):400-12. doi: 10.1208\/s12248-014-9578-7. Epub 2014 Feb 21. PMID: 24557747; PMCID: PMC4012039.<\/a>

      <\/span><\/li>
    • Alessandri K, Sarangi BR, Gurchenkov VV, Sinha B, Kie\u00dfling TR, Fetler L, Rico F, Scheuring S, Lamaze C, Simon A, Geraldo S, Vignjevic D, Dom\u00e9jean H, Rolland L, Funfak A, Bibette J, Bremond N, Nassoy P. Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro. Proc Natl Acad Sci U S A. 2013<\/strong> Sep 10;110(37):14843-8. doi: 10.1073\/pnas.1309482110. Epub 2013 Aug 26. PMID: 23980147; PMCID: PMC3773746.<\/a>

      <\/span><\/li>
    • Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Aur\u00e9gan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells. 2013<\/strong> Sep;31(9):1816-28. doi: 10.1002\/stem.1430. PMID: 23712629.<\/a>

      <\/span><\/li>
    • Feyeux M, Bourgois-Rocha F, Redfern A, Giles P, Lefort N, Aubert S, Bonnefond C, Bugi A, Ruiz M, Deglon N, Jones L, Peschanski M, Allen ND, Perrier AL. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Hum Mol Genet. 2012<\/strong> Sep 1;21(17):3883-95. doi: 10.1093\/hmg\/dds216. Epub 2012 Jun 7. PMID: 22678061.<\/a>

      <\/span><\/li>
    • Lefort N, Feyeux M, Bas C, F\u00e9raud O, Bennaceur-Griscelli A, Tachdjian G, Peschanski M, Perrier AL. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Nat Biotechnol. 2008<\/strong> Dec;26(12):1364-6. doi: 10.1038\/nbt.1509. Epub 2008 Nov 23. PMID: 19029913.<\/a><\/span><\/li><\/ul>","__globals__":{"text_color":"globals\/colors?id=secondary"}},"elements":[],"widgetType":"text-editor"},{"id":"7a02d01","elType":"widget","settings":{"space":{"unit":"px","size":60,"sizes":[]}},"elements":[],"widgetType":"spacer"}],"isInner":false}],"isInner":false}]]]> <![CDATA[Contact]]> https://treefrog.fr/contact/ Thu, 01 Apr 2021 09:43:25 +0000 https://treefrog.fr/?page_id=38 GET IN TOUCH

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        ]]> 38 0 0 0 30 Avenue Gustave Eiffel, B\u00e2t A<\/span>
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        TreeFrog Therapeutics Japan KK
        PMC building 4F,
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        <\/span>Minato-ku,
        <\/span>Tokyo 106-0044, JAPAN
        <\/span>        +81 3-6230-9888<\/span><\/a><\/p>","_padding":{"unit":"px","top":"0","right":"0","bottom":"0","left":"0","isLinked":true},"__globals__":{"text_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"text-editor"},{"id":"eada670","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"28fea7d","elType":"widget","settings":{"title":"Hub - uSA","header_size":"h5","__globals__":{"title_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"heading"},{"id":"9d522d3","elType":"widget","settings":{"editor":"

        TreeFrog Therapeutics,
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        Scaling-up cell therapy manufacturing while preserving cell quality

        Contact our team
        Overcoming cell therapy manufacturing bottlenecks

        C-Stem™ is a biomimetic cell culture platform allowing for the mass-production of stem cell- derived therapies with unprecedented cell quality.

        C-Stem technology by TreeFrog Therapeutics

        Scale-up

        C-Stem™ generates scale-independent cell culture micro-environments, allowing to progress to larger bioreactors without changing key parameters.

        Safety

        C-Stem™ perserves genomic integrity and yields mature cell phenotypes,  thereby enhancing the safety of cellular products

        Efficacy

        C-Stem™ delivers functional microtissues, which were shown to improve graft integration and reduce time-to-effect.

        Play Play Play Previous Next
        Step-by-step

        The C-Stem™ process

        #1 industrial-grade microfluidics

        High-throughput stem cell encapsulation

        • GMP encapsulation device
        • Automated, closed, single-use
        • Throughput: > 1,000 capsules per second
        ips cell encapsulation biomimetic 3D stem cell micro-environment
        #2 biomimetic 3D micro-environments

        Self-organization in in vivo-like stem cell microtissues

        • Epiblast structure promotes fast & high-fidelity cell division
        • Capsule lets nutrients, gas and growth factors in & out
        • Capsule protects cellular content from mechanical stress
        #3 Bioreactor scale-up

        Exponential stem cell expansion & differentiation in bioreactors

         
        • >100-fold hPSC amplification per week
        • Best-in-class cell viability, pluripotency & genomic integrity
        • Single-batches of over 10 billion cells in 10L bioreactor
        • Differentiation into functional microtissues in bioreactor
        ips-derived cell therapy scale-up in bioreactor pluripotent stem cell expansion and differentiation Play Play Previous Next
        #4 EASY downstream processing & delivery

        Functional 3D microtissues ready for transplantation

        • Capsule removal in minutes to release cell content
        • Mature cell phenotypes enhance product safety & efficacy
        • 3D microtissue format facilitates handling & delivery
        PARTNERSHIP MODEL

        Our job: to bring the benefits of C-Stem™ as fast as possible to patients through in-house programs and strategic alliances.

        Adapt 2D to 3D

        Our 3D stem cell biology team dedicated R&D platform can adapt existing protocols to C-Stem™ for optimal hPSC amplification and differentiation

        Scale-up early

        Our bioproduction team can develop bioreactor-based manufacturing processes to secure commercial-scale batches for non-clinical and early clinical phases

        Enhance delivery

        Our scientists can provide expertise in logistics, delivery formats and medical devices to maximize the clinical convenience and therapeutic benefits of the product

        Optimize manufacturing

        Our encapsulation and analytical development teams can provide continuous support for the optimization of manufacturing processes

        Partner with us

        Contact our team !






          C-Stem™ technology: Scaling-up iPS-derived cell therapy manufacturing in bioreactors

          TreeFrog Therapeutics has developed C-Stem, a technology allowing for the mass-production of iPS-derived cell therapies in large-scale bioreactors. C-stem is based on a proprietary high-throughput cell encapsulation technology which generates over 1,000 capsules per second. Each stem cell capsule constitutes a biomimetic micro-environment which recapitulates an in-vivo like stem cell niche. In the capsule, pluripotent stem cells self-organize to form an epiblast-like 3D stem cell microtissue which promotes exponential pluripotent stem cell growth, maintenance of homogenous pluripotency and high-fidelity chromosome segregation (preservation of genomic integrity). But the capsule is also protecting stem cells during manufacturing proceses. In fact, C-Stem allows for the scale-independent exponential amplification of hiPSCs and their differentiation into functional 3D microtissues in industrial bioreactors.

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          C-Stem<\/span>\u2122<\/span>\u00a0perserves genomic integrity and yields mature cell phenotypes,\u00a0 thereby enhancing the safety of cellular products<\/span><\/p>","text_color":"#FFFFFF","__globals__":{"text_color":""}},"elements":[],"widgetType":"text-editor"}],"isInner":true},{"id":"912ac6a","elType":"column","settings":{"_column_size":33,"_inline_size":null},"elements":[{"id":"30eb83b","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/05\/EFFICACY.gif","id":2041}},"elements":[],"widgetType":"image"},{"id":"b3dd563","elType":"widget","settings":{"title":"Efficacy","header_size":"h4","title_color":"#15EDA3"},"elements":[],"widgetType":"heading"},{"id":"16f57dd","elType":"widget","settings":{"editor":"

          C-Stem<\/span>\u2122<\/span>\u00a0delivers functional microtissues, which were shown to improve graft integration and reduce 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          • GMP encapsulation device<\/li>
          • Automated, closed, single-use<\/li>
          • Throughput: > 1,000 capsules per second<\/li><\/ul>","__globals__":{"text_color":"globals\/colors?id=b3d04f9"}},"elements":[],"widgetType":"text-editor"}],"isInner":true},{"id":"b039cf7","elType":"column","settings":{"_column_size":50,"_inline_size":50},"elements":[{"id":"21ffd2d","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2022\/12\/GMP-C-Stem-Platform-cell-therapy-manufacturing-TreeFrog-iPS.jpg","id":5681,"alt":"GMP C-Stem Platform cell therapy manufacturing TreeFrog iPS","source":"library"},"image_size":"portfolio_masonry_large"},"elements":[],"widgetType":"image"},{"id":"51bbe07","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"}],"isInner":true}],"isInner":true},{"id":"f23acf9","elType":"widget","settings":{"space":{"unit":"px","size":124,"sizes":[]},"space_mobile":{"unit":"px","size":10,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"5f3fff5","elType":"section","settings":{"structure":"20","animation":"fadeInUp","qode_parallax_speed":"0"},"elements":[{"id":"2597a5f","elType":"column","settings":{"_column_size":50,"_inline_size":50},"elements":[{"id":"6de86ec","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/ips-cell-encapsulation-biomimetic-3D-stem-cell-micro-environment-scaled.jpg","id":379},"image_size":"portfolio_masonry_large"},"elements":[],"widgetType":"image"}],"isInner":true},{"id":"539b087","elType":"column","settings":{"_column_size":50,"_inline_size":50},"elements":[{"id":"3853a6b","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"},{"id":"31cc829","elType":"widget","settings":{"title":"#2 biomimetic 3D micro-environments","header_size":"h5","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","__globals__":{"title_color":"globals\/colors?id=d76acbd"}},"elements":[],"widgetType":"heading"},{"id":"9f90f18","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"0a75060","elType":"widget","settings":{"title":"Self-organization in in vivo-like stem cell microtissues","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","__globals__":{"title_color":""},"title_color":"#EDB944"},"elements":[],"widgetType":"heading"},{"id":"b50d9ae","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"5da7e89","elType":"widget","settings":{"editor":"
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            • Capsule lets nutrients, gas and growth factors in & out<\/li>
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              \u00a0<\/div>
              • >100-fold hPSC amplification per week<\/li>
              • Best-in-class cell viability, pluripotency & genomic integrity<\/li>
              • Single-batches of over 10 billion cells in 10L bioreactor<\/li>
              • Differentiation into functional microtissues in bioreactor<\/li><\/ul>","__globals__":{"text_color":"globals\/colors?id=bfc53cd"}},"elements":[],"widgetType":"text-editor"}],"isInner":true},{"id":"9e06339","elType":"column","settings":{"_column_size":50,"_inline_size":50},"elements":[{"id":"56a95ad","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/ips-derived-cell-therapy-scale-up-in-bioreactor-pluripotent-stem-cell-expansion-differentiation.jpg","id":396},"image_size":"portfolio_masonry_large"},"elements":[],"widgetType":"image"},{"id":"ff084a6","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"}],"isInner":true}],"isInner":true},{"id":"fbd7c33","elType":"widget","settings":{"space":{"unit":"px","size":124,"sizes":[]},"space_mobile":{"unit":"px","size":17,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"b103b00","elType":"section","settings":{"structure":"20","animation":"fadeInUp","qode_parallax_speed":"0"},"elements":[{"id":"a1d0d49","elType":"column","settings":{"_column_size":50,"_inline_size":50},"elements":[{"id":"86b96fe","elType":"widget","settings":{"slides":[{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/3D-microtissue-capsule-removal.jpg","id":420},"_id":"0a68a60","type":"video","video":{"url":"https:\/\/youtu.be\/AXGp7j6QK88","is_external":"","nofollow":"","custom_attributes":""}},{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/ips-derived-cardiac-microtissue-beating.jpg","id":437},"_id":"88ec7c0","type":"video","video":{"url":"https:\/\/youtu.be\/2A2ymkX9cIo","is_external":"","nofollow":"","custom_attributes":""}}],"slideshow_height":{"unit":"px","size":447,"sizes":[]},"slides_per_view":"1","thumbs_ratio":"169","height":{"unit":"px","size":577,"sizes":[]},"pagination":"","image_size_size":"portfolio_masonry_large","height_mobile":{"unit":"px","size":235,"sizes":[]}},"elements":[],"widgetType":"media-carousel"}],"isInner":true},{"id":"0dfd63f","elType":"column","settings":{"_column_size":50,"_inline_size":50},"elements":[{"id":"362b64d","elType":"widget","settings":{"space_mobile":{"unit":"px","size":13,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"1f77624","elType":"widget","settings":{"title":"#4 EASY downstream processing & delivery","header_size":"h5","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","__globals__":{"title_color":"globals\/colors?id=accent"}},"elements":[],"widgetType":"heading"},{"id":"18c4fc6","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]},"space_mobile":{"unit":"px","size":24,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"e60c29c","elType":"widget","settings":{"title":"Functional 3D microtissues ready for transplantation","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","__globals__":{"title_color":"globals\/colors?id=accent"}},"elements":[],"widgetType":"heading"},{"id":"989c4ac","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"daa5194","elType":"widget","settings":{"editor":"
                  \n
                • Capsule removal in minutes to release cell content<\/li>
                • Mature cell phenotypes enhance product safety & efficacy<\/li>
                • 3D microtissue format facilitates handling & delivery<\/li>\n<\/ul>","__globals__":{"text_color":"globals\/colors?id=accent"}},"elements":[],"widgetType":"text-editor"}],"isInner":true}],"isInner":true},{"id":"ad1a9c5","elType":"widget","settings":{"space":{"unit":"px","size":124,"sizes":[]},"space_mobile":{"unit":"px","size":30,"sizes":[]}},"elements":[],"widgetType":"spacer"}],"isInner":false}],"isInner":false},{"id":"516c101","elType":"section","settings":{"layout":"full_width","background_background":"classic","qode_parallax_speed":"0","__globals__":{"background_color":"globals\/colors?id=secondary"}},"elements":[{"id":"17b6568","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"f8a37a4","elType":"widget","settings":{"space":{"unit":"px","size":62,"sizes":[]},"space_mobile":{"unit":"px","size":20,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"52aaeec","elType":"section","settings":{"structure":"20","animation":"fadeInUp","qode_parallax_speed":"0"},"elements":[{"id":"c14d729","elType":"column","settings":{"_column_size":50,"_inline_size":75.789},"elements":[{"id":"0e58dfa","elType":"widget","settings":{"title":"PARTNERSHIP MODEL","header_size":"h5","__globals__":{"title_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"heading"},{"id":"61fe257","elType":"widget","settings":{"title":"Our job: to bring the benefits of C-Stem\u2122 as fast as possible to patients through in-house programs and strategic alliances.","header_size":"h4","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_size":{"unit":"px","size":40,"sizes":[]},"typography_font_weight":"600","typography_line_height":{"unit":"px","size":50,"sizes":[]},"title_color":"#FFFFFF","typography_font_size_mobile":{"unit":"px","size":28,"sizes":[]},"typography_line_height_mobile":{"unit":"em","size":1.1,"sizes":[]}},"elements":[],"widgetType":"heading"}],"isInner":true},{"id":"9970f21","elType":"column","settings":{"_column_size":50,"_inline_size":23.69},"elements":[],"isInner":true}],"isInner":true},{"id":"50df143","elType":"widget","settings":{"space":{"unit":"px","size":62,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"59026c2","elType":"section","settings":{"structure":"40","animation":"fadeInUp","qode_parallax_speed":"0"},"elements":[{"id":"63c45fd","elType":"column","settings":{"_column_size":25,"_inline_size":null},"elements":[{"id":"25b4586","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/05\/2D-3D.gif","id":2039}},"elements":[],"widgetType":"image"},{"id":"9cf524f","elType":"widget","settings":{"title":"Adapt 2D to 3D","header_size":"h4","__globals__":{"title_color":""},"title_color":"#EDB944"},"elements":[],"widgetType":"heading"},{"id":"67c51d9","elType":"widget","settings":{"editor":"

                  Our 3D stem cell biology team dedicated R&D platform can adapt existing protocols to C-Stem\u2122 for optimal hPSC amplification and differentiation<\/span><\/p>","__globals__":{"text_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"text-editor"}],"isInner":true},{"id":"31d8d47","elType":"column","settings":{"_column_size":25,"_inline_size":null},"elements":[{"id":"ef440b0","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/05\/SCALE-UP-BIO.gif","id":2045}},"elements":[],"widgetType":"image"},{"id":"47d46a8","elType":"widget","settings":{"title":"Scale-up early","header_size":"h4","__globals__":{"title_color":""},"title_color":"#15EDA3"},"elements":[],"widgetType":"heading"},{"id":"0a1d30d","elType":"widget","settings":{"editor":"

                  Our bioproduction team can develop bioreactor-based manufacturing processes to secure commercial-scale batches for non-clinical and early clinical phases<\/p>","__globals__":{"text_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"text-editor"}],"isInner":true},{"id":"d275922","elType":"column","settings":{"_column_size":25,"_inline_size":null},"elements":[{"id":"206f61d","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/05\/DELIVERY.gif","id":2054}},"elements":[],"widgetType":"image"},{"id":"776cba7","elType":"widget","settings":{"title":"Enhance delivery","header_size":"h4","__globals__":{"title_color":""},"title_color":"#39D0FF"},"elements":[],"widgetType":"heading"},{"id":"c2259ac","elType":"widget","settings":{"editor":"

                  Our scientists can provide expertise in logistics, delivery formats and medical devices to maximize the clinical convenience and therapeutic benefits of the product<\/p>","__globals__":{"text_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"text-editor"}],"isInner":true},{"id":"ba2e8b0","elType":"column","settings":{"_column_size":25,"_inline_size":null},"elements":[{"id":"8e2d248","elType":"widget","settings":{"image":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/05\/MANUFACTURING.gif","id":2042}},"elements":[],"widgetType":"image"},{"id":"5c46a80","elType":"widget","settings":{"title":"Optimize manufacturing","header_size":"h4","__globals__":{"title_color":""},"title_color":"#5784ED"},"elements":[],"widgetType":"heading"},{"id":"f28365f","elType":"widget","settings":{"editor":"

                  Our encapsulation and analytical development teams can provide continuous support for the optimization of manufacturing processes<\/p>","__globals__":{"text_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"text-editor"}],"isInner":true}],"isInner":true},{"id":"2b3d68d","elType":"widget","settings":{"space":{"unit":"px","size":62,"sizes":[]},"space_mobile":{"unit":"px","size":24,"sizes":[]}},"elements":[],"widgetType":"spacer"}],"isInner":false}],"isInner":false},{"id":"96808c3","elType":"section","settings":{"layout":"full_width","background_background":"classic","qode_parallax_speed":"0","__globals__":{"background_color":""},"background_color":"#EDB944"},"elements":[{"id":"06fd25b","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"f37b82d","elType":"widget","settings":{"space":{"unit":"px","size":96,"sizes":[]},"space_mobile":{"unit":"px","size":51,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"45533ad","elType":"widget","settings":{"anchor":"contact"},"elements":[],"widgetType":"menu-anchor"},{"id":"7fab930","elType":"section","settings":{"structure":"20","qode_parallax_speed":"0"},"elements":[{"id":"a28d323","elType":"column","settings":{"_column_size":50,"_inline_size":29.737,"animation":"fadeInUp"},"elements":[{"id":"54bd95c","elType":"widget","settings":{"title":"Partner with us","header_size":"h5","__globals__":{"title_color":"globals\/colors?id=secondary"}},"elements":[],"widgetType":"heading"},{"id":"25a2309","elType":"widget","settings":{"title":"Contact our team !","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","__globals__":{"title_color":"globals\/colors?id=secondary"}},"elements":[],"widgetType":"heading"},{"id":"f0123b1","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"}],"isInner":true},{"id":"c896442","elType":"column","settings":{"_column_size":50,"_inline_size":70.263,"margin":{"unit":"px","top":"0","right":"0","bottom":"0","left":"0","isLinked":false},"padding":{"unit":"px","top":"0","right":"0","bottom":"0","left":"96","isLinked":false}},"elements":[{"id":"3c3e9a8","elType":"widget","settings":{"cf7":"5771","html_class":"cf7_custom_style_1","_margin":{"unit":"px","top":"-16","right":"0","bottom":"0","left":"0","isLinked":false}},"elements":[],"widgetType":"bridge_cf_7"}],"isInner":true}],"isInner":true},{"id":"7b39964","elType":"widget","settings":{"space":{"unit":"px","size":96,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"995d3d1","elType":"widget","settings":{"editor":"

                  C-Stem\u2122 technology: Scaling-up iPS-derived cell therapy manufacturing in bioreactors<\/h1>\n

                  TreeFrog Therapeutics has developed C-Stem, a technology allowing for the mass-production of iPS-derived cell therapies in large-scale bioreactors. C-stem is based on a proprietary high-throughput cell encapsulation technology which generates over 1,000 capsules per second. Each stem cell capsule constitutes a biomimetic micro-environment which recapitulates an in-vivo like stem cell niche. In the capsule, pluripotent stem cells self-organize to form an epiblast-like 3D stem cell microtissue which promotes exponential pluripotent stem cell growth, maintenance of homogenous pluripotency and high-fidelity chromosome segregation (preservation of genomic integrity). But the capsule is also protecting stem cells during manufacturing proceses. In fact, C-Stem allows for the scale-independent exponential amplification of hiPSCs and their differentiation into functional 3D microtissues in industrial bioreactors.<\/p>"},"elements":[],"widgetType":"text-editor"}],"isInner":false}],"isInner":false}]]]> <![CDATA[Home]]> https://treefrog.fr/ Thu, 01 Apr 2021 10:54:45 +0000 https://treefrog.fr/?page_id=64 Our mission

                  Making cell therapies

                  more efficient & safer more available & affordable

                  to cure millions of patients

                  Meet TreeFrog Therapeutics
                  Next-Gen Cell Therapies

                  Ready-to-graft microtissue formats

                  To unleash the therapeutic potential of
                  stem cell-derived cell therapies

                  Discover our pipeline
                  C-STEM™ TECHNOLOGY

                  Scalable manufacturing
                  with flawless cell quality

                  To meet medical needs in terms of cell volume, lead time, cost and safety

                  Learn about C-Stem™
                  What's new
                  More news

                  TreeFrog Therapeutics I iPS-derived cell therapies I Cell Therapy for all

                  TreeFrog Therapeutics is a cell therapy biotech based in Bordeaux, France. TreeFrog advances a pipeline of allogeneic cell therapies based on human induced pluripotent stem cells (hiPSCs) and develops a breakthrough technology - C-Stem - allowing to scale-up cell therapy manufacturing in bioreactors thus reducing cell therapy costs, to improve cell quality to ensure the genomic safety of cell therapy products, and to enhance the efficacy of cellular therapies through a delivery approach based on 3D microtissues containing mature cell phenotypes (in contrast with cell therapies based single-cell suspensions of progentiors). C-Stem enables exponential iPS cell amplification with high viability, pluripotency and genomic integrity in large-scale stirred-tank bioreactors, thus producing commercial-size single-batches of iPS of over 10 billions cells. Our iPS platform also enables direct differentiation of human pluripotent stem cells into the desired cell type in a ready-to-graft 3D microtissue format. The company founded by Kevin Alessandri & Maxime Feyeux, aims at providing access to safe, efficient and affordable cell therapies for all.

                  ]]> 64 0 0 0 stem cell-derived cell therapies ","header_size":"h4","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","typography_line_height":{"unit":"em","size":1.2,"sizes":[]},"__globals__":{"title_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"heading"},{"id":"827bdbd","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"33107f4","elType":"widget","settings":{"text":"Discover our pipeline","align":"left","border_radius":{"unit":"px","top":"50","right":"50","bottom":"50","left":"50","isLinked":true},"__globals__":{"typography_typography":"","button_text_color":"globals\/colors?id=0536720","background_color":""},"typography_typography":"custom","typography_font_family":"Quicksand","typography_font_size":{"unit":"px","size":20,"sizes":[]},"typography_font_weight":"600","button_text_color":"#FFFFFF","background_color":"#15EDA3","link":{"url":"\/cell-therapy-pipeline-ips-derived-cell-therapies-allogeneic-stem-cell-therapies\/","is_external":"","nofollow":"","custom_attributes":""}},"elements":[],"widgetType":"button"}],"isInner":true},{"id":"1e8f71f","elType":"column","settings":{"_column_size":50,"_inline_size":33.289},"elements":[],"isInner":true}],"isInner":true}],"isInner":false}],"isInner":false},{"id":"f2e2d5a","elType":"section","settings":{"layout":"full_width","height":"full","background_background":"slideshow","background_color":"#3C4B66","background_video_link":"\/wp-content\/uploads\/2021\/04\/exponential-hiPSC-expansion-in-10L-bioreactor-WEB.mp4","background_overlay_background":"classic","background_overlay_opacity":{"unit":"px","size":0.8,"sizes":[]},"qode_parallax_speed":"0","__globals__":{"background_color":"globals\/colors?id=secondary","background_overlay_color":"","background_overlay_color_b":"globals\/colors?id=bfc53cd"},"background_overlay_color_b":"#ED5C57","background_video_fallback":{"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/04\/home-treefrog-scalable-manufacturing.jpg","id":419},"background_overlay_color":"#ED5C57","background_slideshow_gallery":[{"id":2188,"url":"https:\/\/treefrog.fr\/wp-content\/uploads\/2021\/06\/C-Stem-ips-derived-cell-therapy-scale-up-manufacturing-mass-production.jpeg"}]},"elements":[{"id":"0f263d2","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"fd8fb60","elType":"section","settings":{"structure":"20","qode_parallax_speed":"0"},"elements":[{"id":"31c9818","elType":"column","settings":{"_column_size":50,"_inline_size":62.105},"elements":[{"id":"f620187","elType":"widget","settings":{"title":"C-STEM\u2122 TECHNOLOGY","header_size":"h6","__globals__":{"title_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"heading"},{"id":"3db1cdf","elType":"widget","settings":{"title":"Scalable manufacturing
                  with flawless cell quality","__globals__":{"title_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"heading"},{"id":"c72fa61","elType":"widget","settings":{"title":"To meet medical needs in terms of \ncell volume, lead time, cost and safety","header_size":"h4","typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","typography_line_height":{"unit":"em","size":1.2,"sizes":[]},"__globals__":{"title_color":"globals\/colors?id=0536720"}},"elements":[],"widgetType":"heading"},{"id":"cfa7778","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"7bad270","elType":"widget","settings":{"text":"Learn about C-Stem\u2122","align":"left","border_radius":{"unit":"px","top":"50","right":"50","bottom":"50","left":"50","isLinked":true},"__globals__":{"typography_typography":"","button_text_color":"globals\/colors?id=0536720","background_color":""},"typography_typography":"custom","typography_font_family":"Quicksand","typography_font_size":{"unit":"px","size":20,"sizes":[]},"typography_font_weight":"600","button_text_color":"#FFFFFF","background_color":"#15EDA3","link":{"url":"\/c-stem-technology-scaling-up-ips-derived-cell-therapy-manufacturing-bioreactors\/","is_external":"","nofollow":"","custom_attributes":""},"button_box_shadow_box_shadow":{"horizontal":0,"vertical":0,"blur":10,"spread":-6,"color":"rgba(0,0,0,0.5)"}},"elements":[],"widgetType":"button"}],"isInner":true},{"id":"1ad04d4","elType":"column","settings":{"_column_size":50,"_inline_size":37.851},"elements":[],"isInner":true}],"isInner":true}],"isInner":false}],"isInner":false},{"id":"8248bc3","elType":"section","settings":{"qode_parallax_speed":"0"},"elements":[{"id":"0797201","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"405ebfa","elType":"widget","settings":{"space":{"unit":"px","size":32,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"36b0984","elType":"widget","settings":{"title":"What's new ","header_size":"h5","__globals__":{"title_color":""},"typography_typography":"custom","typography_font_family":"Quicksand","typography_font_size":{"unit":"px","size":20,"sizes":[]},"typography_font_weight":"600","title_color":"#3C4B66"},"elements":[],"widgetType":"heading"},{"id":"a2cddcb","elType":"widget","settings":{"space":{"unit":"px","size":12,"sizes":[]}},"elements":[],"widgetType":"spacer"},{"id":"d8f229b","elType":"widget","settings":{"classic_columns":"2","classic_title_tag":"h6","classic_show_excerpt":"","classic_meta_data":["date"],"classic_meta_separator":"\/\/\/","classic_show_read_more":"","classic_read_more_text":"Read More \u00bb","cards_meta_separator":"\u2022","cards_read_more_text":"Read More \u00bb","full_content_posts_per_page":4,"full_content_thumbnail":"thumbnail","full_content_meta_separator":"\/\/\/","pagination_page_limit":"5","pagination_prev_label":"« Previous","pagination_next_label":"Next »","classic_thumbnail_size_size":"large","_animation":"fadeInUp","classic_posts_per_page":4,"text":"Load More","load_more_no_posts_custom_message":"No more posts to show"},"elements":[],"widgetType":"posts"},{"id":"90711e1","elType":"section","settings":{"text_align":"center","qode_parallax_speed":"0"},"elements":[{"id":"889cca1","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"f51875c","elType":"widget","settings":{"text":"More news","align":"center","border_radius":{"unit":"px","top":"50","right":"50","bottom":"50","left":"50","isLinked":true},"__globals__":{"typography_typography":"globals\/typography?id=primary","button_text_color":"globals\/colors?id=0536720","background_color":""},"typography_typography":"custom","typography_font_family":"Quicksand","typography_font_weight":"600","button_text_color":"#FFFFFF","size":"md","typography_font_size":{"unit":"px","size":20,"sizes":[]},"link":{"url":"\/ips-cell-therapy-news\/","is_external":"","nofollow":"","custom_attributes":""},"icon_align":"right","background_color":"#3C4B66","button_box_shadow_box_shadow":{"horizontal":0,"vertical":0,"blur":10,"spread":-6,"color":"rgba(0,0,0,0.5)"}},"elements":[],"widgetType":"button"}],"isInner":true}],"isInner":true},{"id":"b0f7baa","elType":"widget","settings":[],"elements":[],"widgetType":"spacer"}],"isInner":false}],"isInner":false},{"id":"297dba2","elType":"section","settings":{"layout":"full_width","background_background":"classic","qode_parallax_speed":"0","__globals__":{"background_color":"globals\/colors?id=0536720"}},"elements":[{"id":"3a80bd8","elType":"column","settings":{"_column_size":100,"_inline_size":null},"elements":[{"id":"d8a376a","elType":"widget","settings":{"editor":"

                  TreeFrog Therapeutics I iPS-derived cell therapies I Cell Therapy for all<\/h1>

                  TreeFrog Therapeutics is a cell therapy biotech\u00a0based in Bordeaux, France. TreeFrog advances a pipeline of allogeneic cell therapies based on human induced pluripotent stem cells (hiPSCs) and develops a breakthrough technology -\u00a0C-Stem - allowing to scale-up cell therapy manufacturing in bioreactors thus reducing cell therapy costs, to improve cell quality to ensure the genomic safety of cell therapy products, and to enhance the efficacy of cellular therapies through a delivery approach based on 3D microtissues containing mature cell phenotypes (in contrast with cell therapies based single-cell suspensions of progentiors). C-Stem enables exponential iPS cell amplification with high viability, pluripotency and genomic integrity in large-scale stirred-tank bioreactors, thus producing commercial-size single-batches of iPS of over 10 billions cells. Our iPS platform also enables direct differentiation of human pluripotent stem cells into the desired cell type in a ready-to-graft 3D microtissue format. The company founded by Kevin Alessandri & Maxime Feyeux, aims at providing access to safe, efficient and affordable cell therapies for all.<\/p>","__globals__":{"text_color":"globals\/colors?id=secondary","typography_typography":"globals\/typography?id=primary"}},"elements":[],"widgetType":"text-editor"}],"isInner":false}],"isInner":false}]]]> <![CDATA[Legal]]> https://treefrog.fr/legal/ Mon, 12 Apr 2021 12:17:09 +0000 https://treefrog.fr/?page_id=1728 Legal

                  The website www.treefrog.fr is a publication of Tree Frog Therapeutics.

                   

                  Address:

                  30 avenue Gustave Eiffel Bâtiment A
                  33600 Pessac – France

                   

                   

                  Publication Director : Kevin Alessandri

                   

                  The website is hosted by OVH – 2, rue Kellermann 59083 Roubaix France.

                  ]]> 1728 0 0 0 The website<\/span> <\/span>www.treefrog.fr<\/a> <\/span>is a publication of Tree Frog Therapeutics.<\/span><\/p>\n

                   <\/p>\n

                  Address:<\/p>

                  30 avenue Gustave Eiffel<\/span>
                  B\u00e2timent A<\/span>
                  33600 Pessac \u2013 France<\/span>
                  <\/p>\n

                   <\/p>\n

                   <\/p>\n

                  Publication Director : Kevin Alessandri
                  <\/p>\n

                   <\/p>\n

                  The website is hosted by OVH \u2013 2, rue Kellermann 59083 Roubaix France.<\/p>"},"elements":[],"widgetType":"text-editor"}],"isInner":false}],"isInner":false}]]]> <![CDATA[Credits]]> https://treefrog.fr/credits/ Mon, 12 Apr 2021 13:58:41 +0000 https://treefrog.fr/?page_id=1802 クレジット

                   

                  ウェブデザイン、学術写真＆映像 : TreeFrog Therapeutics

                  モーションデザイン動画＆GIFs : honni.fr

                  ]]> 1802 0 0 0

                  \u30af\u30ec\u30b8\u30c3\u30c8<\/h2>

                  \u00a0<\/p>

                  \u30a6\u30a7\u30d6\u30c7\u30b6\u30a4\u30f3\u3001\u5b66\u8853\u5199\u771f\uff06\u6620\u50cf : TreeFrog Therapeutics<\/p>

                  \u30e2\u30fc\u30b7\u30e7\u30f3\u30c7\u30b6\u30a4\u30f3\u52d5\u753b\uff06GIFs : honni.fr<\/a><\/p><\/div>"},"elements":[],"widgetType":"text-editor"}],"isInner":false}],"isInner":false}]]]>